Everything you learn from this Web site should be discussed with your physician. Even though I have strong opinions about various treatment options, you should consult with a physician before embarking on a treatment plan.
This patient oriented web site presented by Dr. James Wittig of The Mount Sinai Medical Center in New York City. It will be helpful for all newly diagnosed osteosarcoma patients and their families: James C. Wittig, M.D.
The latest Osteosarcoma study that I am aware of, Best record for ten-year Osteosarcoma treatment showed a 92% 5-year overall survival rate and an 84% event-free 10-year survival rate but the therapy was, at best a difficult, four month, cell-toxic chemotherapy and at worst, a year long cell-toxic chemotherapy. Depending on the stage of bone tumor growth, a total knee replacement can be necessary as well
List of top Osteosarcoma treatment centers
 |
Back
|
| The University of Texas M. D.
Anderson Cancer Center 1515 Holcombe Blvd, Houston, TX 77030 1-800-392-1611 (USA) / 1-713-792-6161 M.D. Anderson Cancer Center Web site Back
|
|
| Integrative Medicine
Outpatient Center Memorial Sloan-Kettering 65th Street 303 East 65th Street New York, NY 10021 Memorial Sloan-Kettering Cancer Center Web site Back |
|
 |
More to come |
Superior survival in treatment of primary nonmetastatic pediatric
osteosarcoma of the extremity.
Wilkins RM, Cullen JW, Odom L, Jamroz BA, Cullen PM, Fink K, Peck SD, Stevens
SL, Kelly CM, Camozzi AB.
Institute for Limb Preservation at Presbyterian/St. Luke's Medical Center,
Denver, Colorado 80210, USA.
BACKGROUND: A protocol to treat osteosarcoma of the extremity was developed at
two local institutions.
METHODS: The study involved a dose-intensified neoadjuvant (pre-operative) protocol of intravenous doxorubicin and intra-arterial cisplatin administered repetitively until maximum angiographic response was noted.
Definitive surgery was delayed until > or =90% reduction in tumor neovascularity was documented.
Prospective assessment of serial arteriograms was highly accurate (94%) in predicting histological response and assisted in surgical planning.
After resection, if patients were determined to be good responders (> or =90% tumor necrosis), they underwent a 4-month postoperative course with the same agents.
Poor responders (<90% necrosis) were treated with alternative agents for 12 months from diagnosis.
Forty-seven assessable patients with primary, high-grade, nonmetastatic osteosarcoma of the extremity were included in this analysis.
The median age was 15 years (range, 7-21 years).
RESULTS: Patients underwent an average of four preoperative intra-arterial courses.
Forty-three patients underwent limb-preservation procedures, and 41 had >90% tumor necrosis.
With an average follow-up of 92 months (range, 20-178 months), 39 patients were continuously disease free, 3 died of disease, 1 died of other causes, and 4 have no evidence of disease 11 to 51 months after relapse (all pulmonary metastases).
There were no local recurrences.
Kaplan-Meier analysis demonstrated a 10-year overall survival of 92% and an event-free survival of 84%.
CONCLUSIONS: This study demonstrates excellent survival with a
dose-intensified neoadjuvant protocol. Future endeavors should involve a
multi-institutional randomized study comparing this approach with another
multiagent intravenous neoadjuvant protocol.
Publication Types:
* Clinical Trial
* Multicenter Study
PMID: 12794015 [PubMed - indexed for MEDLINE]
back
